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Research Associate, Cell Line Development – Assay Development

Location: South San Francisco, CA

Company Description:

Ambys Medicines is an early-stage biotech company researching and developing medicines that harness the natural regenerative properties of the liver for patients suffering from devastating liver diseases.  Founded by Third Rock Ventures with world-renowned academic thought leaders and a substantial collaboration with Takeda, Ambys is pioneering novel approaches to liver restoration and regeneration.  The company’s core technologies of cell therapy, gene therapy, drug therapy, and unique translational models are the foundation of our research and development platform.  We at Ambys believe that revolutionary medicines result from bold research, performed to the highest standards, following the biology, putting patient needs first and performed by a collaborative, committed, and curious team.  We are seeking smart, creative, and motivated people to join our team and become part of the Ambys adventure.

Position Summary:

We are seeking a Research Associate with knowledge of mammalian cell line manipulation and in-vitro assay development experience required to advance our understanding of biological processes underlying the development of a variety of liver diseases.  This individual will join a dynamic and growing multidisciplinary team focused on the development of new in-vitro assay methods using mammalian cell lines that model human disease states. A key component of the position will be to provide regular, high quality assay results to other team members and troubleshoot and develop approaches to optimize experimental procedures. The candidate will be flexible enough to work across projects supporting the many goals of the company. The successful candidate will work with direct supervision of a Scientist but show strong independence and a willingness to advance within a quickly growing company.

The successful candidate will be a decisive and results-oriented individual who is flexible, team-oriented, creative and able to excel in a multi-project, fast-track environment. If you thrive in a culture of collaboration and have an entrepreneurial spirit, we’d like to meet you.

Job Requirements:

  • B.S. or M.S. in a biological science discipline
  • At least 2 years relevant experience in bio-pharma or Academic R&D
  • Experience working with suspension and adherent mammalian cells
  • Hands on experience in design and execution of key activities associated with cell line generation and workflow optimization required; including transfection, drug selection, verifiable single cell cloning, high throughput clone /pool screening, cell banking and clone analysis
  • Execution of existing protocols and flexibility to generate new protocols and assay designs
  • Experience with transfection of siRNA, shRNA and/or CRISPRs or lentiviral transduction delivery desirable
  • Experience in performing some of the following molecular/ biochemical/ immunochemical assays required- flow cytometry, qPCR, SDS-PAGE, ELISA and Western blotting
  • Experience with primary and ex-vivo hepatic cell culture models desirable
  • Experience with common laboratory software (SoftmaxPro, GraphPad Prism, etc.)
  • Familiarity with ELN software preferred
  • Must be willing to work with ex-vivo preclinical samples and possibly blood samples (whole blood and blood components)

If you would like to be considered for an opportunity at Ambys Medicines, please submit your CV with the title of the position in the subject line to

The well-being of our employees and their families is important to us. We offer comprehensive and competitive health, financial, paid time off and many other benefits designed to promote the health and financial well-being of our employees and their families.

Note to Recruitment Agencies: Please do not forward any agency resumes. Ambys Medicines is not responsible for any fees related to resumes that are unsolicited.

Ambys Medicines is an equal opportunity employer.