About Liver Diseases

Impacting Millions and on the Rise

In pathological states, failing hepatocyte regeneration drives disease progression, while other cells types change liver architecture
HEALTHY
Normal hepatocyte regeneration & liver restoration
Injury Halted
Injury Halted
1
Liver Injury
The liver is continually working to naturally regenerate itself in response to injury from diet, lifestyle or viral infection.
2
Host Immune Response
In a normally functioning liver, initial hepatocyte injury initiates an immune response, clearing damaged or dead cells.
3
Normal Regeneration
Hepatocyte regeneration and restore liver function
4
Normal Restoration
DISEASED
Pathologic hepatocyte regeneration & changing liver architecture
Injury Persists
Injury Persists
5
Broader Immune Response
Stellate Cell
Kupffer Cell
If the injury persists, the sustained inflammation results in a broader, more aggressive immune response, diminishing hepatocyte regenerative capacity
6
Activation of myofibroblasts
ECM
Collagen
Myofibroblast
Activated myofibroblasts depost extracellular matrix (ECM), including collagen, leading to progressive fibrosis.
7
Excessive ECM abnormal stiffness
ECM
Collagen
Excessive ECM changes the liver’s architecture leading to abnormal stiffness, restricting the ability of hepatocytes to regenerate.
8
Fibrosis & cirrhosis
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