About Liver Disease

Impacting Millions and on the Rise

Mortality rates due to chronic liver disease and cirrhosis are on an alarming upward trajectory, with rising death rates in the United States and around the world.
1.3M+
Global Deaths and Increasing
123M
WW prevalence for compensated and de-compensated cirrhosis
2.2M
US prevalence for compensated and de-compensated cirrhosis
Only8,896
Liver transplants performed in the US
The Urgent Need

Urgent Need for Therapeutic Progress

Despite these staggering statistics and significant advances in treating some liver diseases such as hepatitis C, little progress has been made to address the life-threatening complications of end-stage liver disease.

New interventions to manage the morbidity and mortality of end-stage liver disease are needed urgently.

In people with end-stage liver disease, the liver’s natural ability to regenerate itself is compromised to the point where the body can no longer create and maintain a sufficient number of hepatocytes needed to conduct vital biosynthetic, metabolic and detoxifying functions. This results in life-threatening disease complications and high morbidity.

While liver transplantation is a viable and curative option, many patients are ineligible. For those who are eligible, the number of patients who could potentially benefit from transplant are far outstripped by the available supply of donor organs.

Translating Biological Insights to Deliver Breakthrough Therapeutics

Deeply understanding and interrogating the biological processes that lead to recurring liver injury, which in turn inhibits the liver’s innate ability to regenerate itself and maintain hepatocyte homeostasis, is a major focus of our work at Ambys.

We are rapidly translating these insights about liver injury to advance breakthrough therapies that can spur liver regeneration and restore function.

Click through to learn more about liver disease progression.
In pathological states, failing hepatocyte regeneration drives disease progression, while other cells types change liver architecture
HEALTHY
Normal hepatocyte regeneration & liver restoration
Injury Halted
Injury Halted
1
Liver Injury
The liver is continually working to naturally regenerate itself in response to injury from diet, lifestyle or viral infection.
2
Host Immune Response
In a normally functioning liver, initial hepatocyte injury initiates an immune response, clearing damaged or dead cells.
3
Normal Regeneration
Hepatocyte regeneration and restore liver function
4
Normal Restoration
DISEASED
Pathologic hepatocyte regeneration & changing liver architecture
Injury Persists
Injury Persists
5
Broader Immune Response
Stellate Cell
Kupffer Cell
If the injury persists, the sustained inflammation results in a broader, more aggressive immune response, diminishing hepatocyte regenerative capacity
6
Activation of myofibroblasts
ECM
Collagen
Myofibroblast
Activated myofibroblasts depost extracellular matrix (ECM), including collagen, leading to progressive fibrosis.
7
Excessive ECM abnormal stiffness
ECM
Collagen
Excessive ECM changes the liver’s architecture leading to abnormal stiffness, restricting the ability of hepatocytes to regenerate.
8
Fibrosis & cirrhosis
Top